Code the command button Click event:

' First tell it to do what it is supposed to do.
' Then ...
[SomeOtherControl].SetFocus
Me!CommandButtonName.Enabled = False

Then how are you going to enable it again?

This is possible, but requires a little forethought.

- What control should receive the focus before the command button is
disabled?

- When should the button be re-enabled?  When a new record is selected?
 When a field value changes?  When the form re-opens?, etc.

The basic logic is:
'air code

Sub cmdButton_Click()

'run your code

'set the focus to another control
Me.OtherControl.SetFocus

'Disable this button
cmdButton.Enabled = False

End Sub

Many times, I'll Enable or Disable a button depending on value in a
field.  Therefore, I'll put something like this into the OnCurrent event
of the form:

'more air code
Sub Form_Current()

If Me!Status = "Processed" then
    'move the focus off of the button, if it has it
    if screen.activecontrol.name = "cmdButton" then
        me.othercontrol.setfocus
        me.cmdbutton.enabled = false
    end if
else
    me.cmdButton.enabled = true
end if